Santos Edward Ortega was born in New York City on June 30, 1899, to parents Rafael (born in Venezuela and of Spanish descent) and Isabella (née Corbett, from Ireland) Ortega.
Ortega initially had aspirations of joining the priesthood and studied briefly at the St. Joseph's Seminary of the De La Salle Christian Brothers in Pocantico Hills, New York, but changed his mind after landing a series of small acting roles in a series of Broadway productions.
He began his career when he was 17 in the theater in "an extravaganza at the old Hippodrome Theater. Later, he went on tour with a singing group, returning to New York City to appear on the Broadway stage including roles in Jeb (1946), Puppets of Passion (1927), What Never Dies (1926-1927), What's the Use (1926), and Marilyn's Affairs.
As radio stations began to come on the air in large numbers, radio programs began to gain momentum, thus opening up new opportunities for Ortega. He first worked in radio in comedy, appearing on a variety show, Blackstone Plantation, where he played a character named Don Rodrigo. Ortega later said that he was hired for the role after a casting director hired the young unknown based on seeing Ortega's name, assuming that he would be perfect for the role.
Despite Ortega's ethnic-sounding name, and the fact that he did have Latino origins on his father's side, he did not speak Spanish. He came to learn that if he convincingly mastered a Spanish dialect, more work would come his way, and it did.
He served as straight man for the duo of Frank Crumit and Julius Sanderson. Ortega said, "It was a song and patter show, and I provided the laughter." He went on to be active in the medium, starring in The Adventures of Nero Wolfe (1943–1944) and narrating Gang Busters, as well as Stroke of Fate. Perhaps his most famous and notable radio role was Commissioner Weston on The Shadow. He played the title role in Bulldog Drummond (1942–43) and was heard in the daytime radio serials Valiant Lady (as Edward Curran), Perry Mason, 1948's Roger Kilgore, Public Defender, and as the title character in The Adventures of Charlie Chan (1947–1948), The Affairs of Peter Salem from 1949 to 1953, and Hannibal Cobb (1950–1951).
Throughout the 1930s and 1940s and into the 1950s and early 1960s, the prolific Ortega lent his remarkable range of voice characterizations to numerous other radio drama series such as Inner Sanctum, The Mysterious Traveler, Suspense, Casey Crime Photographer, The Eternal Light, The Columbia Workshop, The Big Story, Perry Mason, You Are There, Dimension X, and X Minus One. He also originated the radio role of Inspector Queen on The Adventures of Ellery Queen.
Ortega died on April 10, 1976, in Broward General Hospital in Fort Lauderdale, Florida, while he was visiting in that area. Survivors included a son, a daughter and a sister. A memorial service was held April 25, 1976, at the Church of the Heavenly Rest in New York City.